Background and Interest

· Statistical and research design methods; Informatics, data integration and interpretation

· Genomic research for dissecting genetic contributors to human complex traits and their interactions

· Genomic platform implementation and application: Genome-Wide Association Studies (GWAS) and Next-Generation Sequencing studies (NGS)

· Biostatistical and bioinformatic software development

· Large-scale statistical genetics computation; parallel statistical computation; -omics platform/databases/knowledgebase implementation, integration and application

· Computational annotation and analysis for genetic variants. Copy number variation annotation and analysis.

· Genomic and transcriptomic computational analysis and annotations

· Pharmacogenomics

· Genomic diagnostics; Personalized medicine

· Meta-analysis; survival analysis

· Clinical trial; cross-sectional studies

Computer Software

· SequenceVariantAnalyzer (SVA) – Software for analyzing genetic variants discovered in large-scale resequencing projects (; PLoS Genet 2010;6(6):e1000991 and 2010;6(9): e1001111; Bioinformatics 2011;27(14):1998-2000.  600+ registered users.)

· WGAViewer - Software for genomic annotation of whole genome association studies. (~dg48/WGAViewer/download.php, Ge et al. Genome Research 2008;18(4):640-3; 1000+ registered users).

· PipeCMD – Computational pipeline for whole genome association quality control and analyses (used in Science 2007;317(5840):944-7 and Nature 2009:461, 399-401).

· SNPExpress- Software for alternative splicing expression analyses (~dg48/SNPExpress/ PLoS Biology, 2008; 6(12): e1000001.).

Genomic medicine and diagnostics

· Inventor for: Interleukin 28B polymorphism (IL28B) test for hepatitis C infection treatment efficacy, licensed to LabCorp, Co. (Current revenue $20 million) and Quest Diagnostics Inc.; publication: Nature 2009:461, 399-401.

· Inventor for: ITPA test for hepatitis C infection treatment adverse effect, licensing pending; publication: Nature. 2010;464(7287):405-8.

· Other inventions for HIV infection, metachondramatosis, metacephaly diagnostics, etc.

Awards and Professional Activities

· North Carolina Educational Event Award, North Carolina Biotechnology Center, 2008

· Awardee, one of 25 "rising stars " named by Genome Technology magazine, 2009-2010

· Awardee, David H. Murdock Research Institute research grant,  2011

· Reviewer - The Federal Austrian Ministry of Science and Research, Austrian National Genome Research Programme. Bioinformatics Integration Network III, 2008

· Reviewer - The 58th Annual American Society of Human Genetics meeting, Philadelphia, PA, Nov 2008, topic #16: Mapping, linkage and linkage disequilibrium, 2008

· Reviewer – Department of Veterans Affairs, 2010

· Reviewer – American Journal of Human Genetics; PLoS Genetics; Genome Research; BMC genomics; BMC Bioinformatics; Bioinformatics; Human Genetics; Human Immunology; Human Mutation; Hypertension; American Heart Journal; Diabetes Metabolism Research and Reviews; Epilepsy and Behavior

· Editor - Frontiers in Statistical Genetics and Methodology

· Invited speaker - WGAViewer: A Software for Genomic Annotation of Whole Genome Association Studies: Usage in Discovering Major Determinants for HIV-1 Host Control. GlaxoSmithKline. Research Triangle, NC; Jan 2008 and Feb 2008.

· Invited faculty – “HIV Host Genomics Hands-on-Computer Workshop” Feb 2008, The 15th Conference on Retroviruses and Opportunistic Infections (CROI 2008), Boston, MA.

· Instructor - “Demonstration of Methods for Performing Whole-Genome Association Studies,” March 2008, Duke University, Durham NC.

· Invited speaker: A Pipeline for Genome-Wide Association Analyses and Annotation: Engines for Discovering Major Determinants for HIV-1 Host Control. Washington University in St. Louis, MO; Sep 2008.

· Invited faculty - “Whole Genome Association Studies: Understanding the Genetic Basis of Susceptibility to Infectious Diseases.” The 57th American Society of Tropical Medicine and Hygiene (ASTMH) pre-annual meeting course, Dec 2008, New Orleans, LA.  

· Invited speaker: Japanese National Hepatitis Expert Meeting. Karuizawa, Japan; Aug 2010.

· Invited speaker: UMCG seminar series. University Medical Center Groningen, the Netherlands; Nov 2010.

· Invited speaker: Illumina Webinar series. Illumina Inc; Feb 2011.

· Invited speaker: BGI Bio-IT-APAC Conference & Expo, Beijing Genomic Institute (BGI), Shenzhen, China; July 2011

· Invited speaker: Fudan University seminar series, Children’s Hospital, Shanghai, China; July 2011

· Invited speaker: China Heart Congress, Beijing, China; August 2011

· Invited speaker: Japan Digestive Disease Week 2011, Fukuoka, Japan; October 2011

· Member - American Public Health Association

· Member - American Society of Human Genetics

· Member – American Heart Association

Education & Research Experience

Center for Human Genome Variation (CHGV); Department of Biostatistics and Bioinformatics

Duke University, Durham, NC, USA

Assistant Professor. Jan. 2009 – present.

Head, Biostatistics and Bioinformatics Team, CHGV

Led 4 genomic research projects; Participating in over 10 genomic research projects.

Center for Human Genome Variation, Institute for Genome Sciences & Policy,

Duke University, Durham, NC, USA

Postdoctoral fellow. Sep. 2006 – Dec. 2008. Advisor: Professor David B. Goldstein.

Medical College of Georgia, Augusta, GA, USA

Postdoctoral fellow. Feb. 2005 – Sep 2006. Advisor: Professor Harold Snieder.

Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

PhD. Biostatistics and Genetic Epidemiology. July 2004. Advisor: Professor Dongfeng Gu.

Shanghai Medical University (currently Fudan University School of Medicine), Shanghai, China

Bachelor of Medicine. Preventive Medicine. July 1999.

Peer-reviewed Publications (ordered by scientific/clinical impact)

1. Ge D*, Fellay J*, Thompson AJ*, Simon JS*, Shianna KV, Urban TJ, Heinzen EL, Qiu P, Bertelsen AH, Muir AJ, Sulkowski M, McHutchison JG, Goldstein DB. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 2009:461, 399-401.

Featured in Nature: news & views: Genomics: Hepatitis C virus gets personal. Nature 2009; 461 (357-358).

Nature: Outlook: Pharmacogenomics: playing the odds. Nature. 2011;474(7350):S9-10.

Licensed to: LabCorp Inc.; Quest Diagnostics Inc.

Citations: 524

2. Fellay J*, Thompson AJ*, Ge D*, Gumbs CE, Urban TJ, Shianna KV, et al. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature. 2010;464(7287):405-8. (* Equal authors) {Fellay, 2010 #320}

3. Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O'hUigin C, Kidd J, Kidd K, Khakoo SI, Alexander G, Goedert JJ, Kirk GD, Donfield SM, Rosen HR, Tobler LH, Busch MP, McHutchison JG, Goldstein DB, Carrington M. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009; 461, 798-801.

4. Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietilainen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Borglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Bottcher Y, Olesen J, Breuer R, Moller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Rethelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA, Group, Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Lim Yoon J, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Jonsson EG, Terenius L, Agartz I, Petursson H, Nothen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K, Collier DA, Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I. Common variants conferring risk of schizophrenia. Nature 2009:460(7256):744-7

5. Stefansson H, Rujescu D, Cichon S, Pietilainen OP, Ingason A, Steinberg S, Fossdal R, Sigurdsson E, Sigmundsson T, Buizer-Voskamp JE, Hansen T, Jakobsen KD, Muglia P, Francks C, Matthews PM, Gylfason A, Halldorsson BV, Gudbjartsson D, Thorgeirsson TE, Sigurdsson A, Jonasdottir A, Jonasdottir A, Bjornsson A, Mattiasdottir S, Blondal T, Haraldsson M, Magnusdottir BB, Giegling I, Moller HJ, Hartmann A, Shianna KV, Ge D , Need AC, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Paunio T, Toulopoulou T, Bramon E, Di Forti M, Murray R, Ruggeri M, Vassos E, Tosato S, Walshe M, Li T, Vasilescu C, Muhleisen TW, Wang AG, Ullum H, Djurovic S, Melle I, Olesen J, Kiemeney LA, Franke B, Kahn RS, Linszen D, van Os J, Wiersma D, Bruggeman R, Cahn W, Germeys I, de Haan L, Krabbendam L, Sabatti C, Freimer NB, Gulcher JR, Thorsteinsdottir U, Kong A, Andreassen OA, Ophoff RA, Georgi A, Rietschel M, Werge T, Petursson H, Goldstein DB, Nothen MM, Peltonen L, Collier DA, St Clair D, Stefansson K. Large recurrent microdeletions associated with schizophrenia. Nature . 2008;455(7210):232-6.

6. Fellay J, Shianna KV *, Ge D *, Colombo S *, Ledergerber B *, Weale M *, Zhang K, Gumbs C, Castagna A, Cossarizza A, Cozzi-Lepri A, De Luca A, Easterbrook P, Francioli P, Mallal S, Martinez-Picado J, Miro JM, Obel N, Smith JP, Wyniger J, Descombes P, Antonarakis SE, Letvin NL, McMichael AJ, Haynes BF, Telenti A, Goldstein DB. A whole-genome association study of major determinants for host control of HIV-1. Science . 2007;317(5840):944-7. (* Equal authors) (Citations: 390)

7. Thomas R, Apps R, Qi Y, Gao X, Male V, O'HUigin C, O'Connor G, Ge D, et al. HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C. Nat Genet. 2009;41(12):1290-4.

8. Ge D, Ruzzo EK, Shianna KV, He M, Pelak K, Heinzen EL, Need AC, Cirulli ET, Maia JM, Zhu M, Singh A, Allen AS, Goldstein DB. SVA: Software for Annotating and Visualizing Sequenced Human Genomes. Bioinformatics, 2011;27(14):1998-2000. (software: )

9. Zhu Q *, Ge D*, Maia JM, Zhu M, Petrovski S, Dickson SP, Heinzen EL, Shianna KV, Goldstein DB. A Genome-Wide Comparison of the Functional Properties of Rare and Common Genetic Variants in Humans. American Journal of Human Genetics. 2011;88(4):458-68.

10. Pelak K*, Shianna KV*, Ge D*, Maia JM, Zhu M, Smith JP, et al. The characterization of twenty sequenced human genomes. PLoS Genet. 2010;6(9): e1001111.

11. Sobreira NLM, Cirulli ET, Avramopoulos D, Wohler E, Oswald GL, Stevens EL, Ge D, et al. Whole-Genome Sequencing of a Single Proband Together with Linkage Analysis Identifies a Mendelian Disease Gene. PLoS Genet 2010;6(6):e1000991.

12. Todd J, Goldstein DB, Ge D, Christie J, Palmer, SM. The State of Genome-Wide Association Studies in Pulmonary Disease: A New Perspective. American Journal of Respiratory and Critical Care Medicine. 2011. In press.

13. Thompson AJ, Muir AJ, Sulkowski MS, Patel K, Tillmann HL, Clark PJ, Naggie S, Fellay J, Ge D, McCarthy JJ et al: Hepatitis C trials that combine investigational agents with pegylated interferon should be stratified by interleukin-28B genotype. Hepatology 2010, 52(6):2243-2244.

14. Thompson AJ, Clark PJ, Singh A, Ge D, et al. Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients. J Hepatol. 2011.

15. Thompson AJ, Fellay J, Patel K, Tillmann HL, Naggie S, Ge D, et al. Variants in the ITPA Gene Protect Against Ribavirin-Induced Hemolytic Anemia and Decrease the Need for Ribavirin Dose Reduction. Gastroenterology. 2010;139(4):1181-9.

16. Thompson AJ, Muir AJ, Sulkowski MS, Ge D, et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology. 2010;139(1):120-9 e18.

17. Walley NM, Julg B, Dickson SP, Fellay J, Ge D, Walker BD, Carrington M, Cohen MS, de Bakker PI, Goldstein DB, Shianna KV, Haynes BF, Letvin NL, McMichael AJ, Michael NL, Weintrob AC. The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression. Cell Host Microbe 2009; 5 (5) : 408-10.

18. Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KL, Hunt P, Ge D, Heinzen EL, Maia JM, Shianna KV, Weale ME, Cherkas LF, Clement G, Spector TD, Gibson G, Goldstein DB. A Genome-wide Study of Common SNPs and CNVs in Cognitive Performance in the CANTAB battery. Hum Mol Genet 2009.

19. Pillai SG, Ge D *, Zhu G*, Kong X*, Shianna KV, Need AC, S. F, Hersh CP, Bakkgators, Rennard SI, Lomas D, Silverman EK, Goldstein DB. A Genome-wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of two Major Susceptibility Loci. PLoS Genet . 2009; 5(3): e1000421. doi:10.1371/journal.pgen.1000421 (* Equal authors)

20. Need AC *, Ge D * , Maia J, Shianna KV, Feng S, Strittmatter WJ, McEvoy JP, Keefe RSE, St Jean PL, Giegling I, Hartmann AM, M?ller H, Ruppert A, Fraser G, Crombie C, Francks C, St.Clair D, Roses AD, Muglia P, Rujescu D, Goldstein DB. A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia. PLoS Genet. 2009; 5(2):e1000373.(* Equal authors)

21. Heinzen E *, Ge D *, Cronin KD, Maia J, Shianna KV, Gabriel W, Welsh-Bohmer KA, Hulette CM, Denny T, Goldstein DB. Tissue specific genetic control of gene expression and alternative splicing: Implications for the study of human complex traits. PLoS Biol . 2008; 6(12): e1000001. (* Equal authors)

22. Ge D , Zhang K, Need AC, Martin O, Fellay J, Urban TJ, Telenti A, Goldstein DB. WGAViewer: Software for genomic annotation of whole genome association studies. Genome Research. 2008;18(4):640-3. (citations: 87)

23. Price AL, Weale ME, Patterson N, Myers SR, Need AC, Shianna KV, Ge D , Rotter JI, Torres E, Taylor KD, Goldstein DB, Reich D. Long-range LD can confound genome scans in admixed populations. Am J Hum Genet 2008 . 83(1):132-5; author reply 135-9.

24. Cavalleri GL, Weale ME, Shianna KV, Singh R, Lynch JM, Grinton B, Szoeke C, Murphy K, Kinirons P, O'Rourke D, Ge D , Depondt C, Claeys KG, Pandolfo M, Gumbs C, Walley N, McNamara J, Mulley JC, Linney KN, Sheffield LJ, Radtke RA, Tate SK, Chissoe SL, Gibson RA, Hosford D, Stanton A, Graves TD, Hanna MG, Eriksson K, Kantanen AM, Kalviainen R, O'Brien TJ, Sander JW, Duncan JS, Scheffer IE, Berkovic SF, Wood NW, Doherty CP, Delanty N, Sisodiya SM, Goldstein DB. Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. Lancet Neurol. 2007;6(11):970-80.

25. Valdes AM, Loughlin J, Timms KM, van Meurs JJ, Southam L, Wilson SG, Doherty S, Lories RJ, Luyten FP, Gutin A, Abkevich V, Ge D, Hofman A, Uitterlinden AG, Hart DJ, Zhang F, Zhai G, Egli RJ, Doherty M, Lanchbury J, Spector TD. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am J Hum Genet 2008;82(6):1231-40.

26. Cronin KD, Ge D, Manninger P, Linnertz C, Rossoshek A, Orrison BM, Bernard DJ, El-Agnaf OM, Schlossmacher MG, Nussbaum RL, Chiba-Falek O. Expansion of the Parkinson Disease-Associated SNCA-Rep1 Allele Up-Regulates Human {alpha}-Synuclein in Transgenic Mouse Brain. Hum Mol Genet 2009.

27. Need AC, Keefe RS, Ge D, Grossman I, Dickson S, McEvoy JP, Goldstein DB. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. Eur J Hum Genet 2009; 17 (7) : 946-57 .

28. Ge D , Su S, Zhu H, Dong Y, Wang X, Harshfield GA, Treiber FA, Snieder H. Stress-Induced Sodium Excretion. A New Intermediate Phenotype to Study the Early Genetic Etiology of Hypertension? Hypertension 2009;53:262-269

29. Ge D , Gooljar SB, Kyriakou T, Collins LJ, Swaminathan R, Snieder H, Spector TD, O'Dell SD. Association of Common JAK2 Variants With Body Fat, Insulin Sensitivity and Lipid Profile. Obesity (Silver Spring) 2008;16(2) : 492-6.

30. Ge D, Zhu H, Huang Y, Treiber FA, Harshfield GA, Snieder H, Dong Y. Multilocus analyses of Renin-Angiotensin-aldosterone system gene variants on blood pressure at rest and during behavioral stress in young normotensive subjects. Hypertension . 2007 ;49(1):107-12.

31. Ge D, Young TW, Wang X, Kapuku GK, Treiber FA, Snieder H. Heritability of arterial stiffness in black and white American youth and young adults. Am J Hypertens 2007;20(10) : 1065-72.

32. Kapuku GK, Ge D, Vemulapalli S, Harshfield GA, Treiber FA, Snieder H. Change of genetic determinants of left ventricular structure in adolescence: longitudinal evidence from the Georgia cardiovascular twin study. Am J Hypertens 2008;21(7):799-805.

33. Oberg S, Ge D, Cnattingius S, Svensson A, Treiber FA, Snieder H, Iliadou A. Ethnic differences in the association of birth weight and blood pressure the georgia cardiovascular twin study. Am J Hypertens 2007;20(12):1235-41.

34. Zhu H, Yan W, Ge D , Treiber FA, Harshfield GA, Kapuku G, Snieder H, Dong Y. Relationships of cardiovascular phenotypes with healthy weight, at risk of overweight, and overweight in US youths. Pediatrics 2008;121(1) : 115-22.

35. Wang L, Li B, Lu X, Zhao Q, Li Y, Ge D, Li H, Zhang P, Chen S, Chen R, Qiang B, Gu D. A functional intronic variant in tyrosine hydroxylase (TH) gene confers risk of essential hypertension in northern Chinese Han population. Clin Sci (Lond) 2008.

36. Dalageorgou C, Ge D , Jamshidi Y, Nolte IM, Riese H, Savelieva I, Carter ND, Spector TD, Snieder H. Heritability of QT Interval: How Much Is Explained by Genes for Resting Heart Rate? J Cardiovasc Electrophysiol 2007.

37. Morell RJ, Brewer CC, Ge D , Snieder H, Zalewski CK, King KA, Drayna D, Friedman TB. A twin study of auditory processing indicates that dichotic listening ability is a strongly heritable trait. Hum Genet 2007;122(1):103-11.

38. Zhu H, Yan W, Ge D, Treiber FA, Harshfield GA, Kapuku G, Snieder H, Dong Y. Cardiovascular characteristics in American youth with prehypertension. Am J Hypertens 2007;20(10):1051-7.

39. Jamshidi Y, Snieder H, Ge D , Spector TD, O'Dell SD. The SH2B gene is associated with serum leptin and body fat in normal female twins. Obesity (Silver Spring) . 2007;15(1):5-9.

40. Healey PR, Mitchell P, Gilbert CE, Lee AJ, Ge D , Snieder H, Spector TD, Hammond CJ. The inheritance of peripapillary atrophy. Invest Ophthalmol Vis Sci 2007;48(6):2529-34.

41. Weili Y, He B, Yao H, Dai J, Cui J, Ge D , Zheng Y, Li L, Guo Y, Xiao K, Fu X, Ma D. Waist-to-height ratio is an accurate and easier index for evaluating obesity in children and adolescents. Obesity (Silver Spring) 2007;15(3):748-52.

42. Jamshidi Y, Gooljar SB, Snieder H, Wang X, Ge D , Swaminathan R, Spector TD, O'Dell SD. SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women. Atherosclerosis 2007; 194 (2) : e26-33

43. Ge D, Dong Y, Wang X, Treiber FA, Snieder H. The Georgia Cardiovascular Twin Study: influence of genetic predisposition and chronic stress on risk for cardiovascular disease and type 2 diabetes.

44. Twin Res Hum Genet . 2006;9(6):965-70.

45. Spencer-Jones NJ*, Ge D *, Snieder H, Perks U, Swaminathan R, Spector TD, Carter ND, O'Dell SD. AMP-kinase alpha2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women. Journal of Medical Genetics. 2006 ;43(12):936-42. (* Joint authors.)

46. Gu D, Ge D, Snieder H, He J, Chen S, Huang J, Li B, Chen R, Qiang B. Association of alpha-1A adrenergic receptor gene variants on chromosome 8p21 with human stage-2 hypertension. Journal of Hypertension , 2006;24(6):1057-1064.

47. Kupper N, Ge D, Treiber FA, Snieder H . Tracking of blood pressure and underlying hemodynamics in European and African American adolescents. Stable heritabilities and expression of new genes. Hypertension , 2006 47(5):948-54 .

48. Gu D, Su S, Ge D, Chen S, Huang J, Li B, Chen R, Qiang B. An Association Study with 33 SNPs in 11 Candidate Genes for Hypertension in Chinese. Hypertension , 2006;47(6):1147-54.

49. Herold SE, Young TW, Ge D, Snieder H, Lovrekovic GZ. Sleep Disordered Breathing in Pediatric Patients with Tetralogy of Fallot. Pediatric Cardiology , 2006;27(2):243-9.

50. de Lange M, Andrew T, Snieder H, Ge D, Futers TS, Standeven K, Spector TD, Grant PJ and Ariens RAS. Joint linkage and association of 6 single nucleotide polymorphisms in the factor XIII-A subunit gene point to V34L as the main functional locus. Arteriosclerosis, Thrombosis, and Vascular Biology . 2006 Aug;26(8):1914-9.

51. Yang W, Huang J, Yao C, Su S, Liu D, Ge D , Gu D. Linkage and linkage disequilibrium analysis of the lipoprotein lipase gene with lipid profiles in Chinese hypertensive families. Clinical Science (Lond). 2005;108(2):137-142.

52. Ge D, Huang J, Yang W, Zhao J, Shen Y, Qiang B, Gu D. Linkage analysis of chromosome 1 with essential hypertension and blood pressure quantitative traits in Chinese families. Annals of Human Genetics . 2005;69(Pt 1):45-54.

53. Ge D , Huang J, He J, Li B, Duan X, Chen R, Gu D. beta2-Adrenergic receptor gene variations associated with stage-2 hypertension in northern Han Chinese. Annals of Human Genetics . 2005;69(Pt 1):36-44.

54. Li B, Ge D , Wang Y, Zhao W, Zhou X, Gu D, Chen R. G Protein beta3 Subunit Gene Variants and Essential Hypertension in the Northern Chinese Han Population. Annals of Human Genetics . 2005;69(Pt 4):468-473.

55. Chen S, Yan W, Huang J, Ge D, Yao Z, Gu D. Association analysis of the variant in the regulatory subunit of phosphoinositide 3-kinase (p85alpha) with Type 2 diabetes mellitus and hypertension in the Chinese Han population. Diabetic Medicine . 2005;22(6):737-743.

56. Yan W, Yang X, Zheng Y, Ge D , Zhang Y, Shan Z , Simu H , Sukerobai M , Wang R . The Metabolic Syndrome in Uygur and Kazak Population. Diabetes Care . 28(10):2554-5, 2005.

57. Zhou X, Huang J, Chen J, Zhao J, Ge D , Yang W, Gu D. Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population. Thrombosis Research . 2004;113(3-4):181-186.

58. Gu D, Ge D, He J, Li B, Chen J, Liu D, Chen J, Chen R. Haplotypic analyses of the aldosterone synthase gene CYP11B2 associated with stage-2 hypertension in northern Han Chinese. Clinical Genetics . 2004;66(5):409-416.

59. Li B, Ge D, Wang Y, Zhao W, Zhou X, Gu D, Chen R. Lipoprotein lipase gene polymorphisms and blood pressure levels in the Northern Chinese Han population. Hypertension Research . 2004;27(6):373-378.

60. Gu F, Ge D, Huang J, Chen J, Yang W, Gu D. Genetic susceptibility loci for essential hypertension and blood pressure on chromosome 17 in 147 Chinese pedigrees. Journal of Hypertension . 2004;22(8):1511-1518.

61. Gu D, Ge D. The New Genetics in Hypertension: Asia Pacific Perspective. Paper presented at: 3rd Asian-Pacific Congress of Hypertension; April 3-7, 2004; Singapore.

62. Yang W, Huang J, Ge D , Yao C, Duan X, Shen Y, Qiang B, Gu D. Lipoprotein lipase gene is in linkage with blood pressure phenotypes in Chinese pedigrees. Human Genetics. 2004;115(1):8-12.

63. Ge D, Yang W, Huang J, Yao C, Xu X, Gan W, Zhao J, Liu D, Wang X, Duan X, Hui R, Shen Y, Yao Z, Qiang B, Gu D. Linkage analysis of 2q14-q23 and 5q32 with blood pressure quantitative traits in Chinese sib pairs. Journal of Hypertension . 2003;21(2):305-310.

64. Yang W, Huang J, Ge D, Yao C, Duan X, Gan W, Huang G, Zhao J, Hui R, Shen Y, Qiang B, Gu D. Variation near the region of the lipoprotein lipase gene and hypertension or blood pressure levels in Chinese. Hypertension Research. 2003;26(6):459-464.

65. Yang WJ, Huang JF, Yao CL, Fan ZJ, Ge D , Gan WQ, Huang GY, Hui RT, Shen Y, Qiang BQ, Gu DF. Evidence for linkage and association of the markers near the LPL gene with hypertension in Chinese families. Journal of Medical Genetics. 2003;40(5):e57.